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SCIENTIFIC PUBLICATIONS
  1. SILMAN RE, Chard T, Lowry PJ, Smith I, Young IM (1976) Human fetal pituitary peptides and parturition. Nature 260, 716-718.
  2. Smith, I, Mullen PE, SILMAN RE, Snedden W, Wilson BW (1976) The absolute identification of melatonin in human plasma cerebrospinal fluid. Nature 260, 718-819.
  3. SILMAN RE, Holland D, Chard T, Lowry PJ, Hope J, Robinson JS, Thorburn GD (1978) The ACTH 'family tree' of the rhesus monkey - changes with development. Nature 276, 526-528.
  4. SILMAN RE, Leone RM, Hooper RJL, Preece MA (1979) Melatonin, the pineal gland and human puberty. Nature 282, 301-303.
  5. Roebuck, MM, Jones CT, Holland D, SILMAN RE (1980) In vitro effects of high molecular weight forms of ACTH in the sheep foetal adrenal gland. Nature 284. 616-618.
  1. 1. Mullen PE, SILMAN RE (1977) The Pineal and Psychiatry: A Review. Psychol Med 7, 407-417.
  2. SILMAN RE, Chard T, Boyd N (1977) Fetal Endocrinology. In: J Barnes, M Newton (eds) Scientific Foundations in Obstetrics and Gynaecology. London, Heinemann Medical Books Limited, 359-369.
  3. Chard T, SILMAN RE (1981) Pituitary peptides in primate fetuses. In: Fetal Endocrinology, Academic Press, pp 303-318.
  4. SILMAN RE (1982) The synthesis and secretion of hormonal peptides by the developing pituitary. In: CT Jones (ed) Biochemical Development of the Fetus and the Neonate. Vol 1. Elsevier/North Holland Biomedical Press, pp 473-494.
  5. Young IM, SILMAN RE (1982) Pineal methoxyindoles in the human. In: J Reiter (ed) The Pineal Gland. Vol 3. CRC Press, pp189-218.
  6. SILMAN RE, Young IM, Chard T (1986) Fetal endocrinology. In E Philipp, J Barnes, M Newton (eds) Scientific Foundations of Obstetrics and Gynaecology, 3rd edition. Wm. Heinemann Medical Books, pp 486-490.
  7. SILMAN RE (1991) Melatonin and the human GnRH pulse generator. J Endocrinol 128, 7-11.
  8. SILMAN RE, Young IM, Chard T (1991) Fetal Endocrinology In E Philipp, M Setchell, J Ginsburg (eds) Scientific Foundations of Obsterics & Gynaecology 4th Edition. Butterworth Heinemann pp 337-341.
  9. SILMAN RE (1992) Melatonin, the clinical perspective in man. Biochem Soc Trans 20, 315-317.
  10. SILMAN RE (1993) Melatonin, a contraceptive for the nineties. Eur J Obs Gyne & Repro Biol 49, 3-9.
  11. SILMAN RE (2010) Catastrophe and homeostasis. Criminal Behaviour and Mental Health 20, 177-189
  1. Smith, I, Mullen PE, SILMAN RE, Snedden W, Wilson BW (1976) The absolute identification of melatonin in human plasma cerebrospinal fluid. Nature 260, 718-819.
  2. Mullen PE, SILMAN RE (1977) The Pineal and Psychiatry: A Review. Psychol Med 7, 407-417.
  3. Wilson B, Snedden W, SILMAN RE, Smith I, Mullen PE (1977) A gas chromatography mass spectrometry method for the quantitative analysis of melatonin in plasma and cerebrospinal fluid. Ann Biochem 81, 283-291.
  4. Mullen PE, Linsell C, SILMAN RE, Edwards RE, Carter S, Hooper J, Leone RM, Laude C, Smith I, Towell P (1978) The human pineal: new approaches and prospects. J Psychosomatic Res 22, 357-376.
  5. Leone RM, SILMAN RE, Hooper RJL, Finnie MDA, Carter SJ, Edwards R, Smith I, Towell P, Mullen PE (1979) A sensitive and specific assay for 5-methoxy-tryptophol in plasma. J Endocr 82, 243-251.
  6. Hooper RJL, SILMAN RE, Leone RM, Finnie MDA, Carter SJ, Grudzinskas JG, Gordon YB, Holland D, Chard T, Mullen PE, Smith I (1979) Changes in the concentration of 5-methoxytryptophol in the circulation at different phases of the human menstrual cycle. J Endocr 82, 269-274.
  7. Mullen PE, Leone RM, Hooper RJL, Smith I, SILMAN RE, Finnie MDA, Carter S, Linsell C (1979) Pineal 5-methoxytryptophol in man. Psychoneuroendocrinology 2, 117-126.
  8. melatonin in the peripheral circulation using gas chromatography mass spectrometry. Prog Brain Res 52, 263-265.
  9. Linsell C, Mullen PE, SILMAN RE, Leone RM, Finnie MDA, Carter S, Hooper RJL, Smith I, Francis P (1979) The measurement of the daily fluctuations of 5-methoxytryptophol in human plasma. Prog Brain Res 52.
  10. Carter SJ. Laude CA, Smith I, Leone RM. Hooper RJL, SILMAN RE, Finnie MDA, Mullen PE, Larson-Carter DL (1979) Plasma 5-methoxytryptophol and the pineal gland. J Endocr 83, 35-40.
  11. Hooper RJL, SILMAN RE, Leone RM, Finnie MDA, Carter SJ. Savage M, Preece M, Smith I, Mullen PE (1979) The immediate response of circulating 5-methoxytryptophol to insulin induced hypoglycaemic stress. J Endocr 83, 193-197.
  12. Smith I, Larson-Carter DL, Laude CA, Leone RM, SILMAN RE, Carter SJ, Francis P, Mullen PE, Hooper RJL, Finnie MDA (1979) O-acetyl 5-methoxytryptophol - tentative identification of pineal glands. Prog Brain Res 52, 259-261.
  13. SILMAN RE, Hooper RJL, Leone RM, Edwards R, Grudzinskas JG, Gordon YB, Chard T, Savage M, Smith I, Mullen PE (1979) 5-methoxytryptophol and pituitary function in man. Prog Brain Res 52, 267-269.
  14. Carter T, Laude CA, Smith I, Leone RM, SILMAN RE, Hooper RJL, Larson-Carter DL, Finnie MDA, Mullen PE (1979) 5-methoxytryptophol in rat pineal glands and other tissues.
  15. SILMAN RE, Leone RM, Hooper RJL, Preece MA (1979) Melatonin, the pineal gland and human puberty. Nature 282, 301-303.
  16. Preece MA, Cameron N, Baines Preece JC, SILMAN RE (1980) Auxological and serum, hormonal changes during puberty. In; E Cacciari, A Prader (eds) Pathophysiology and Puberty. London, New York, Academic Press, pp 79-88.
  17. Hooper RJL, SILMAN RE, Leone RM, Finnie MDA (1980) The role of mass spectrometry in the field of pineal physiology. In: A Frigerio, M McCamish (eds) Recent Developments in Mass Spectrometry in Biochemistry and Medicine, No 6. Amsterdam, Elsevier Scientific Publishing Company, pp 109-120.
  18. Leone RM, SILMAN RE, Hooper RJL, Young IM (1981) The use of GC-MS in the study of the pineal indole O-acetyl-5-methoxytryptophol. In CD Mathews, RF Seamark (eds). Pineal Function. Elsevier/North Holland Biomedical Press, pp 13-18.
  19. Hooper RJL, SILMAN RE, Leone RM, Young IM (1981) The development of a plasma assay for 5 methoxytryptamine using gas chromatography mass spectrometry. In: CD Mathews, RF Seamark (eds) Pineal Function. Elsevier/North Holland Biomedical Press, pp 1-6.
  20. SILMAN RE (1981) 5-methoxy indoles in man. In: A Oksche, P Pevet (eds) The Pineal Organ. Elsevier/North Holland, pp 335-344.
  21. Young IM, SILMAN RE (1982) Pineal methoxyindoles in the human. In: J Reiter (ed) The Pineal Gland. Vol 3. CRC Press, pp189-218.
  22. Skene D, Leone RM, Young IM, SILMAN RE (1983) The assessment of a plasma melatonin assay using gas chromatography mass spectrometry negative chemical ionization mass spectrometry. Biomed Mass Spectrometry 10 (12), 655-659.
  23. Leone RM, SILMAN RE (1984) Melatonin can be differentially metabolised in the rat to produce N-acetyl serotonin in addition to 6-hydroxymelatonin. Endocrinology 114, 1835-1862.
  24. Young IM, Leone RM, Francis P, Stovell P, SILMAN RE (1985) Melatonin is metabolised to N-acetyl serotonin and 6-hydroxy melatonin in man. J Clin Endocrinol Metab 60, 114-119.
  25. Leone RM, SILMAN RE (1985) An investigation of demythlation in the metabolism of methoxytryptamine and methoxytryptophol. J Pineal Res 2, 87-94.
  26. Young IM, Leone RM, SILMAN RE (1985) The mass spectrometric analysis of the urinary metabolites of melatonin and its deuterated analogues confirming their identity as N-acetyl serotonin and 6-hydroxy-melatonin. Biomed Mass Spectrometry 12, 319-337.
  27. Francis PL, Leone AM, Young IM, Stovell P, SILMAN RE (1987) Gas chromatographic mass spectrometric assay for 6-hydroxy melatonin sulfate and 6-hydroxy melatonin glucuronide in urine. Clin Chem 33, 453-457.
  28. Korenman EMD, Watson BW, SILMAN RE (1987) The pattern of motor activity, light and melatonin production in Syrian hamsters. J Pineal Res 4, 99-105.
  29. Leone AM, Francis PL, SILMAN RE The isolation, purification and characterisation of the principal urinary metabolites of melatonin. J Pineal Res 4, 253.
  30. Leone AM, SILMAN RE, Hill BT, Whelan RDH, Shellard SA (1987) Melatonin and its metabolites and ovarian tumor growth inhibition. Neuroendocr Letts 9 (5) 289.
  31. Young IM, Francis PL, Leone AM, Stovell P, SILMAN RE (1988) Constant pineal output and increasing body mass account for declining melatonin levels during human growth and sexual maturation. J Pineal Res 5, 71-85.
  32. Leone AM, SILMAN RE, Hill BT, Whelan RDH, Shellard SA (1988) Growth inhibitory effects of melatonin and its metabolites against ovarian tumour cell lines in vitro. In: D Gupta, A Attanasio, RJ Reiter (eds). Brain Research Promotion, Tubingen, Germany, pp 273-281.
  33. Peniston-Bird J, Bhatt T, Di WL, Kemper A, Staltieri M, Street CA, Vissers R, SILMAN RE (1991) The measurement of melatonin in plasma using High Performance Liquid Chromatography. J Endocrinol 131 40.
  34. Street CA, Di WL, Peniston-Bird J, Kemper A, Vissers R, Bhatt T, SILMAN RE (1991) The purification of the major urinary metabolites of melatonin. J Endocrinol 131 41.
  35. SILMAN RE (1992) Melatonin, the clinical perspective in man. Biochem Soc Trans 20, 315-317.
  36. SILMAN RE (1993) Melatonin, a contraceptive for the nineties. Eur J Obs Gyne & Repro Biol 49 3-9.
  37. Peniston-Bird JF, Di WL, Street CA, Kadva A, Stalteri MA, SILMAN RE (1993) HPLC assay of melatonin in plasma with fluorescence detection. Clinical Chemistry Vol39 No.11, 2242-2247.
  38. Peniston Bird JF, Di WL, Street CA, Edwards R, Little JA, SILMAN RE (1996) An enzyme immunoassay for 6-Sulphatoxy-melatonin in human urine. J Pineal Research 20, 51-56
  39. Street CA, Di WL, Peniston-Bird JF, Patel S, Sadler P, SILMAN RE (1996) The purification and characterisation of biological 6-Sulphatoxy-melatonin and comparison with synthetic 6-Sulphatoxy-melatonin. J Pineal Research 20, 98-114
  40. Di WL, Kadva A, Johnston A, SILMAN RE (1997) Variable bioavailability of oral melatonin. New England Journal of Medicine vol 336 no 13, 1028 - 1029
  41. Di WL, Kadva A, Djahanbakhch O, SILMAN.RE (1998) Radio-immunoassay of bound and free melatonin in plasma. Clinical Chemistry 44 (2), 304 - 310
  42. Di WL, Djahanbakhch O, Kadva A, Street C, SILMAN RE (1999) The pineal and extra-pineal origins of 5-Sulphatoxy N-acetyl-serotonin in humans. J. Pineal Research 26: 221-226
  43. SILMAN RE (2010) Catastrophe and homeostasis. Criminal Behaviour and Mental Health 20, 177-189
  1. SILMAN RE, Chard T, Lowry PJ, Smith I, Young IM (1976) Human fetal pituitary peptides and parturition. Nature 260, 716-718.
  2. SILMAN RE, Chard T, Lowry PJ, Mullen PE, Smith I, Young IM (1977) Human fetal corticotrophin and related pituitary peptides. J Steroid Biochem 8, 553-557.
  3. SILMAN RE, Chard T, Landon J, Lowry PJ, Smith I, Young IM (1977) ACTH and MSH peptides in the human adult and fetal pituitary gland. In: Greidanus Van W (ed). Frontiers of Hormone Research, Basel, Karger 4, 179-187.
  4. Chard T, SILMAN RE, Rees LH (1977) The fetal hypothalamus and pituitary in the initiation of labour. In: J Knight, M O'Connor (eds) The Fetus and Birth, CIBA Foundation Symposium 47, Amsterdam, Elsevier. Excerpta Medica 359-378.
  5. SILMAN RE, Chard T, Boyd N (1977) Fetal Endocrinology. In: J Barnes, M Newton (eds) Scientific Foundations in Obstetrics and Gynaecology. London, Heinemann Medical Books Limited, 359-369.
  6. Lowry PJ, Hope J, SILMAN RE (1977) Evolution of corticotrophin, melanotrophin, corticotrophin-like intermediate lobe peptide and lipotrophin. Proc Vth Cong Endocr, Hamburg 1, 71-76.
  7. Lowry PJ, SILMAN RE, Hope J (1977) Structure and biosynthesis of peptides related to corticotropins and beta melanotropins. Ann NY Acad Sci 294, 49062.
  8. SILMAN RE, Holland D, Chard T, Lowry PJ, Hope J, Robinson JS, Thorburn GD (1978) The ACTH 'family tree' of the rhesus monkey - changes with development. Nature 276, 526-528.
  9. Branchaud CG, Goodyer C, Hall St G, Arato JS, SILMAN RE, Giroud CJP (1978) Steroidogenic activity of hACTH and related peptides in the human neocortex and fetal adrenal cortex in organ culture. Steroids 31, 557-572.
  10. SILMAN RE, Holland D, Chard T, Lowry PJ, Hope J, Rees LH, Thomas AL, Nathanielsz PW (1979) Adrenocorticotrophin-related peptides in adult and foetal sheep pituitary glands. J Endocr 81, 19-34.
  11. Holland D, Silman RE, Chard T, Lowry PJ, Goodyer C, Branchaud C, Giroud C (1979) Corticotrophin and lipotrophin "Family Tree" of the human pituitary gland. J Endocr. , 48-49.
  12. Chard T, SILMAN RE, (1979) Development of hypophysial peptides in the fetal sheep, monkey and human. In: L Zichella, Pancheri (eds). Psychoneuroendocrinology in Reproduction, Elsevier/North Holland and Biomedical Press, pp 409-414.
  13. Lowry PJ, SILMAN RE, Jackson S, Estivariz F (1979) The lipotropin and corticotropin-related peptides of the mammalian pituitary in interaction with the brain-pituitary adrenocortical system. MT Jones, B Gillham, MF Dallman, Chattopadhyay (eds). London, Academic Press.
  14. Roebuck, MM, Jones CT, Holland D, SILMAN RE (1980) In vitro effects of high molecular weight forms of ACTH in the sheep foetal adrenal gland. Nature 284. 616-618.
  15. SILMAN RE, Street C, Holland D, Chard T, Falconer J, Robinson JS (1981) The pars intermedia and the fetal pituitary-adrenal axis. In: D Evered, G Lawrenson G (eds) Peptides of the Pars Intermedia, CIBA Foundation Symposium 81, London, Pitman Medical, pp 180-195.
  16. Chard T, SILMAN RE (1981) Pituitary peptides in primate fetuses. In: Fetal Endocrinology, Academic Press, pp 303-318.
  17. SILMAN RE (1982) The synthesis and secretion of hormonal peptides by the developing pituitary. In:CT Jones (ed) Biochemical Development of the Fetus and the Neonate. Vol 1. Elsevier/North Holland Biomedical Press, pp 473-494.
  18. SILMAN RE, Young IM, Chard T (1986) Fetal endocrinology. In E Philipp, J Barnes, M Newton (eds) Scientific Foundations of Obstetrics and Gynaecology, 3rd edition. Wm. Heinemann Medical Books, pp 486-490.
  19. SILMAN RE, Young IM, Chard T (1991) Fetal Endocrinology In E Philipp, M Setchell, J Ginsburg (eds) Scientific Foundations of Obsterics & Gynaecology 4th Edition. Butterworth Heinemann pp 337-341.
  1. Wilson B, Snedden W, SILMAN RE, Smith I, Mullen PE (1977) A gas chromatography mass spectrometry method for the quantitative analysis of melatonin in plasma and cerebrospinal fluid. Ann Biochem 81, 283-291.
  2. Leone RM, SILMAN RE, Hooper RJL, Finnie MDA, Carter SJ, Edwards R, Smith I, Towell P, Mullen PE (1979) A sensitive and specific assay for 5-methoxy-tryptophol in plasma. J Endocr 82, 243-251.
  3. Leone RM, SILMAN RE, Hooper RJL, Carter S, Finnie MDA, Edwards R, Smith I, Francis P, Mullen PE (1979) A routine assay for methoxytryptophol and melatonin in the peripheral circulation using gas chromatography mass spectrometry. Prog Brain Res 52, 263-265.
  4. Hooper RJL, SILMAN RE, Leone RM, Finnie MDA (1980) The role of mass spectrometry in the field of pineal physiology. In: A Frigerio, M McCamish (eds) Recent Developments in Mass Spectrometry in Biochemistry and Medicine, No 6. Amsterdam, Elsevier Scientific Publishing Company, pp 109-120.
  5. Leone RM, SILMAN RE, Hooper RJL, Young IM (1981) The use of GC-MS in the study of the pineal indole O-acetyl-5-methoxytryptophol. In CD Mathews, RF Seamark (eds). Pineal Function. Elsevier/North Holland Biomedical Press, pp 13-18.
  6. Hooper RJL, SILMAN RE, Leone RM, Young IM (1981) The development of a plasma assay for 5 methoxytryptamine using gas chromatography mass spectrometry. In: CD Mathews, RF Seamark (eds) Pineal Function. Elsevier/North Holland Biomedical Press, pp 1-6.
  7. Skene D, Leone RM, Young IM, SILMAN RE (1983) The assessment of a plasma melatonin assay using gas chromatography mass spectrometry negative chemical ionization mass spectrometry. Biomed Mass Spectrometry 10 (12), 655-659.
  8. Young IM, Leone RM, SILMAN RE (1985) The mass spectrometric analysis of the urinary metabolites of melatonin and its deuterated analogues confirming their identity as N-acetyl serotonin and 6-hydroxy-melatonin. Biomed Mass Spectrometry 12, 319-337.
  9. Francis PL, Leone AM, Young IM, Stovell P, SILMAN RE (1987) Gas chromatographic mass spectrometric assay for 6-hydroxy melatonin sulfate and 6-hydroxy melatonin glucuronide in urine. Clin Chem 33, 453-457.
  10. Leone AM, Francis PL, SILMAN RE The isolation, purification and characterisation of the principal urinary metabolites of melatonin. J Pineal Res 4, 253.
  11. Peniston-Bird JF, Di WL, Street CA, Kadva A, Stalteri MA, SILMAN RE (1993) HPLC assay of melatonin in plasma with fluorescence detection. Clinical Chemistry Vol39 No.11, 2242-2247.
  12. Peniston Bird JF, Di WL, Street CA, Edwards R, Little JA, SILMAN RE (1996) An enzyme immunoassay for 6-Sulphatoxy-melatonin in human urine. J Pineal Research 20, 51-56
  13. Street CA, Di WL, Peniston-Bird JF, Patel S, Sadler P, SILMAN RE (1996) The purification and characterisation of biological 6-Sulphatoxy-melatonin and comparison with synthetic 6-Sulphatoxy-melatonin. J Pineal Research 20, 98-114
  14. Di WL, Kadva A, Johnston A, SILMAN RE (1997) Variable bioavailability of oral melatonin. New England Journal of Medicine vol 336 no 13, 1028 - 1029
  15. Di WL, Kadva A, Djahanbakhch O, SILMAN.RE (1998) Radio-immunoassay of bound and free melatonin in plasma. Clinical Chemistry 44 (2), 304 - 310
  1. Menabawey M, SILMAN RE, Rice A, Chard T (1985) Dramatic increase of placental protein 5 levels following injection of small doses of heparin. Br J Obstet Gynaec 92, 207-210.
  2. Fay TN, Jacobs I, SILMAN RE, Grudzinskas JG (1988) Quantitative analysis of proteins secreted by the decidua and trophoblast in the first trimester of pregnancy. In: Mizutani (ed) Placental and Endometrial Proteins. Netherlands, Elsevier, pp 57-60.
  3. Price KM, SILMAN RE, Armstrong P, Grudzinskas JG (1994) Development of a radioimmunoassay for fetal antigen 2. Clin Chim Acta 224: 95-102.
  4. Price KM, SILMAN RE, Grudzinskas JG (1994) Isolation of fetal antigen 2 and assay standardisation. Clin Chim Acta 226: 83-88
  5. Price KM, SILMAN RE, Armstrong P, Teisner B, Grudzinskas JG (1995) The typing of fetal antigen 2 in human amniotic fluid. Clin Chim Acta 236: 181-194
  6. Price KM, SILMAN RE, Armstrong P, Grudzinskas JG (1995) Abnormal amniotic fetal antigen 2 levels in trisomy 18 and trisomy 21. Human Reproduction Vol 10 No 9, 2438-2440
  7. Price KM, Van Lith JMM, SILMAN RE,Mantingh A, Grudzinskas JGG (1998) First trimester maternal serum concentrations of fetal antigen 2 in normal pregnancies and those affected by trisomy 21 Human Reproduction Vol 13 No 6, 1706-1708
  1. SILMAN RE (1991) Melatonin and the human GnRH pulse generator. J Endocrinol 128, 7-11.
  2. SILMAN RE (1992) Melatonin, the clinical perspective in man. Biochem Soc Trans 20, 315-317.
  3. SILMAN RE (1993) Melatonin, a contraceptive for the nineties. Eur J Obs Gyne & Repro Biol 49 3-9.
  4. Kadva A, Di WL, Djahanbakhch O, Monson J, SILMAN RE (1996) Evidence for the Bauman variant in Kallmann's syndrome. Clinical Endocrinol 44, 103-110
  5. Kadva A, Djahanbakhch O, Monson J, Di WL, SILMAN RE (1998) Elevated nocturnal melatonin is a consequence of GnRH deficiency in women with hypothalamic amenorrhoea J Clin Endocrinol Metab Vol 83 No. 10 3653 - 3662
  1. Tabaqchali S, Holland DH, O'Farrell S, SILMAN RE (1984) Typing scheme for Clostridium difficile: its application in clinical and epidemiological studies. Lancet, i, 935-938.
  2. Tabaqchali S, Holland D, O'Farrell S, SILMAN RE, Pullan B (1985) A simple method for the identification of bacteria based on 35S methionine labelled proteins. American Society for Microbiology 269, 344.
  3. SILMAN RE, Holland DT (1986) Protein fingerprinting and microbial identification. IN: R Wakeford (ed). Biotechnology Information 1986, Oxford, Washington DC, IRL Press, pp 3-12.
  4. Tabaqchali S, O'Farrell S, Holland D, SILMAN RE (1986) Method of typing Clostridium difficile based on polyacrylamide gel electrophoresis of 35S methionine labelled proteins. J Clin Microbiol 23, 197-198.
  5. Tabaqchali S, SILMAN RE, Holland D (1987) Automation in clinical microbiology: a new approach to identifying microorganisms by automated pattern matching of proteins labelled with 35S methionine. J Clin Path 40, 1070-1087.

1. Korenman EMD, Watson BW, SILMAN RE (1987) The pattern of motor activity, light and melatonin production in Syrian hamsters. J Pineal Res 4, 99-105.

2. Korenman EMD, Watson BW, SILMAN RE (1988) Activity rhythms of hamsters in a single cage compared to a simulated burrow system. Physiol Behav 43, 459-467

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